We examined effects of a required college health and wellness course on students’ physical activity (PA) attitudes and behaviors. A survey based on models of behavior change was emailed (September 2016 – May 2017) to all students at a liberal arts college. Of 408 students who responded, 217 had completed the course and 191 had not. Students who had taken the course reported more confidence in their ability to improve their physical fitness; found more encouragement from cues to action; and met recommended guidelines for weekly PA more than students who had not taken the course. Compared to males, females had less confidence in their ability to increase PA and improve fitness and overall health. Females perceived barriers to PA as more discouraging and cues to action as less encouraging. Data showed a required college health and wellness course altered students’ PA attitudes and behaviors.